Neurological Lyme disease is tricky to diagnose and to treat. For patients, it can be a long hard road with many decisions being more of an art than a science due to the relative lack of funding for Lyme disease research.

Diagnosis of neurological Lyme disease is notoriously difficult due to its varied and often nonspecific symptoms that can mimic many other conditions. The classic triad of meningitis, cranial neuritis, and radiculoneuritis occurs in only a minority of cases[12]. Many patients experience subtle cognitive issues, fatigue, and mood changes that are easily mistaken for other disorders[9]. Additionally, current diagnostic tests have limitations – antibody tests may be negative in early infection or after antibiotic treatment, and there is no reliable test to determine active infection or treatment success[13]. Clinicians must rely heavily on clinical presentation, exposure history, and ruling out other conditions.

Treatment of neurological Lyme disease also poses challenges. While early treatment with appropriate antibiotics is often successful, delayed diagnosis can lead to more entrenched infection that is harder to eradicate[12]. The optimal antibiotic regimen and duration of treatment for late-stage neurological Lyme disease remains controversial. Some patients experience persistent symptoms even after standard antibiotic courses, leading to debates about the need for longer-term treatment[10]. Additionally, the infection can cause immune system dysfunction that may persist after the bacteria are eliminated[13]. Managing the wide range of neurological and psychiatric symptoms often requires a multidisciplinary approach beyond just antibiotics.

Ten Common Treatments for Neuro Lyme Disease

1. Antibiotic Therapy
   • Doxycycline: Oral antibiotic, effective for early and late Lyme neuroborreliosis[4]
   • Ceftriaxone: Intravenous antibiotic, commonly used for more severe cases[1][4]
   • Cefotaxime: Alternative intravenous antibiotic[4]
   • Penicillin G: Another intravenous option[4]
2. Combination Antibiotic Therapy: Some research suggests using a three-antibiotic cocktail may be more effective for persistent infections[3]
3. Extended Treatment Duration: 14-21 days for early Lyme neuroborreliosis, potentially longer for late-stage cases[4]
4. Herbal Protocols: Some patients explore herbal treatments (see section below, also see Cistus incanus section below.)
5. Claritin: A study found that desloratadine may block the manganese transporter in Borrelia burgdorferi, the bacteria responsible for Lyme disease. Desloratadine, along with other antihistamines like 3-hydroxydesloratadine, as well as yohimbine and tadalafil, demonstrated tight binding to the transporter. Desloratadine’s potential to interfere with the bacteria’s metal transport system, which could potentially inhibit its growth or survival.
6. Supportive Supplements:
   • Systemic enzymes
   • Mangosteen
   • Lithium orotate
   • Coenzyme Q10
   • D-Ribose
   • L-Carnitine Fumerate
   • Magnesium[2], Magnesium Threonate
   • N-Acetyl Cystinine (NAC)
   • Glycine
   • L-Lysine
7. Optimal Nutrition can be crucial in supporting recovery (see section below)
8. Get Enough Quality Sleep. Your body regenerates during sleep. While neuro lyme can make sleep difficult or impossible for stretches, these generally smooth out with time. Consider melatonin as a sleep aid if needed.
9. Detoxification Protocols: Diet changes and other techniques can help the body eliminate toxins and reduce symptoms[2]
10. Infrared Sauna / Heating Pad may weaken the bacteria so antibiotics work better (see section below)
11. Symptomatic Treatment: Addressing specific neurological and psychiatric symptoms with appropriate medications[6]
12. Immune System Support: From non-steroidal anti-inflammatory drugs to more intensive therapies like intravenous immunoglobulin in severe cases[6]
13. EMF Protection: Get away from electromaganetic radiation as much as you can from devices, cell towers, and so on. While the consensus is not firm, research shows that EMF can cause oxidative stress and may even trigger voltage sensing calcium ion channels in nerves to open, causing nerve damage.
14. Integrative Approach: Combining conventional and alternative treatments, tailored to the individual patient’s needs[1][3]
15. Electromedicine: Some patients explore Rife machine therapy, though its effectiveness is debated[2]

It’s important to note that treatment should be personalized and conducted under the supervision of a Lyme-literate healthcare provider. The effectiveness of these strategies can vary among individuals, and some approaches may lack robust scientific evidence.

Top Herbal Treatments for Lyme Disease

Here are some of the most promising herbal options based on scientific studies:

1. Ghanaian quinine (Cryptolepis sanguinolenta)
   This herb showed potent activity against both active and dormant forms of Lyme bacteria. A 7-day treatment with 1% Ghanaian quinine extract was able to eradicate the bacterium in lab dishes, with no regrowth observed.
2. Japanese knotweed (Polygonum cuspidatum)
   Extracts from this plant demonstrated strong antibacterial activity against Lyme bacteria, even at low concentrations.
3. Garlic (Allium sativum)
   Essential oil from garlic cloves showed strong killing activity against persister forms of Lyme bacteria.
4. Sweet wormwood (Artemisia annua)
   This herb contains artemisinin, which has shown effectiveness against Lyme bacteria proteins.
5. Cat’s claw (Uncaria tomentosa)
   Known for its robust antimicrobial effects and ability to enhance DNA repair in healthy cells.
6. Black walnut (Juglans nigra)
   Extracts from this tree have demonstrated effectiveness against Lyme bacteria.
7. Chinese skullcap (Scutellaria baicalensis)
   This herb has shown neuroprotective, antioxidant, and anti-inflammatory properties, as well as the ability to inhibit Lyme bacteria replication.
8. Cinnamon bark
   Essential oil from cinnamon bark killed Lyme bacteria without any regrowth in lab studies.
9. Clove buds
   Like cinnamon bark, essential oil from clove buds showed strong activity against Lyme bacteria.
10. Oregano
    Essential oil from oregano leaves also demonstrated potent killing activity against stationary phase Lyme bacteria.

These herbal treatments show promise in laboratory studies. More research is needed to firmly establish their efficacy and safety in humans. Always consult with a healthcare provider before starting any new treatment regimen.

Cistus incanus for Lyme Disease

1. In vitro effectiveness: Studies have demonstrated that Cistus incanus extracts can be effective against Lyme disease bacteria (Borrelia burgdorferi) in laboratory settings.
2. Mechanism of action: Cistus incanus is believed to work through its potent antimicrobial and anti-inflammatory properties.
3. Biofilm disruption: Some research suggests that Cistus incanus may help break down biofilms, which are protective layers that Lyme bacteria can form to evade antibiotics and the immune system.
4. Additional benefits: Beyond its potential anti-Lyme properties, Cistus incanus is known for its antioxidant content and possible immune-boosting effects.
5. Traditional use: This herb has a long history of use in traditional Mediterranean medicine for various ailments.
6. Safety profile: Generally considered safe when used as a tea or supplement, though more research is needed on long-term use and potential interactions.
7. Forms of use: Commonly consumed as a tea, but also available in tincture and capsule forms.

Cistus incanus shows promise and more clinical research is needed to fully understand its effectiveness in treating Lyme disease in humans. As with any alternative treatment, it should be discussed with a healthcare provider before use, especially in conjunction with other Lyme disease treatments.

Methylene Blue for Lyme Borreliosis Complex

Dr. Joseph Jemsek, from the Jemsek Specialty Clinic in Washington DC, discusses the use of methylene blue (MB) for treating Lyme Borreliosis Complex in a podcast interview with pharmacist Jay Gill. Here are the key points from their discussion:

#1: Don’t buy Methylene blue and use it yourself, it needs to be used under medical supervision. Methylene blue should only be used under proper medical supervision. One important reason for this is the need to screen for glucose-6-phosphate dehydrogenase (G6PD) deficiency before using methylene blue. G6PD is an enzyme that helps protect red blood cells from oxidative stress. In individuals with G6PD deficiency, methylene blue can trigger hemolytic anemia, a condition where red blood cells break down faster than they can be replaced. This potentially dangerous reaction underscores the importance of medical oversight and appropriate testing before using methylene blue as a treatment[26][27].

History and Scientific Literature

Methylene blue has a long history of medical use, dating back to its synthesis in 1876[21]. Recent research, particularly from Johns Hopkins University, has shown that MB can effectively inhibit Bartonella and the spirochete form of Borrelia burgdorferi (the bacteria causing Lyme disease) at clinical doses[17][21]. Studies have also demonstrated MB’s ability to disrupt biofilms, which are protective structures formed by bacteria[20][22].

Effectiveness and Combination Therapy

While not a standalone cure for Lyme disease, Dr. Jemsek has observed positive results when using MB in combination with other Lyme therapies[22]. This aligns with research showing that MB, when combined with other antibiotics like azithromycin or rifampin, can be highly effective against stationary phase Bartonella[19].

Dosing and Administration

The dosing for tick-borne illnesses typically ranges from 4mg twice a day to 50mg twice a day, often starting at the lower end and gradually increasing[19]. It’s crucial to use high-quality, USP grade methylene blue, which should be obtained through a reputable compounding pharmacy with a prescription[20].

Benefits Beyond Antimicrobial Action

In addition to its antimicrobial properties, low-dose MB may aid in nerve regeneration and improve mental clarity[22]. MB also has antioxidant and neuroprotective properties, making it potentially beneficial for various neurological conditions[21].

Side Effects and Contraindications

Common side effects may include blue or green urine, skin discoloration, altered taste, dizziness, and nausea[4]. MB should not be used in patients taking SSRIs, SNRIs, or other medications that increase serotonin levels due to the risk of serotonin syndrome[20]. It’s also important to note that MB requires the enzyme glucose-6-phosphate dehydrogenase (G6PD), and individuals with G6PD deficiency should avoid its use[21]. It will stain your commode, so get some bartender’s friend (Comet) unless you don’t mind a blue commode according to Dr. Jemsek.

In conclusion, while methylene blue shows promise in treating Lyme Borreliosis Complex, it should be used under proper medical supervision and in conjunction with other appropriate therapies. Patients interested in this treatment should consult with a knowledgeable healthcare provider and obtain the medication through a reputable compounding pharmacy.

Optimal Nutrition for Neuro Lyme Disease

Optimal nutrition can play a crucial role in supporting recovery and managing symptoms for those with neurological Lyme disease. Here are some key dietary recommendations:

Anti-Inflammatory Focus

An anti-inflammatory diet is fundamental for managing neuro Lyme symptoms, but don’t overdo it as I did.  Work on finding a balance. You need some inflammation where your body fighting against Lyme bacteria.

– Emphasize low oxalate vegetables, fruits, nuts, seeds, and healthy fats like olive oil[28][29].
– Include fatty cold-water fish rich in omega-3s, such as wild salmon and sardines[30].
– Minimize processed foods, refined carbohydrates, sugar, and industrial seed oils[29].

Support Immune Function

Bolstering the immune system is critical:

– Consume foods high in zinc like oysters, red meat, poultry, and organ meats[30].
– Include vitamin D-rich foods like fatty fish and pastured egg yolks[30].
– Eat foods with vitamin A, found in organ meats, eggs, and orange/yellow vegetables[30].

Promote Brain Health

Supporting brain function is essential for neuro Lyme:

– Ensure adequate intake of vitamin B12 through meat, poultry, fish, and eggs[30].
– Consume DHA-rich seafood like wild salmon and sardines[30].
– Include antioxidant-rich berries, especially blueberries, which may help reduce neuroinflammation[30].

Gut Health Support

Many Lyme patients have compromised gut health due to antibiotic use:

– Focus on probiotic-rich foods like sauerkraut, kimchi, and kefir.
– Include prebiotic foods to feed beneficial gut bacteria.
– Consider temporarily reducing intake of gluten and dairy, as these can be inflammatory for some[31].

Additional Considerations

– Stay well-hydrated with water and electrolyte-rich beverages[32].
– Choose organic produce when possible to minimize pesticide exposure[32].
– Consider supplementation under medical supervision, especially for nutrients like vitamin D, zinc, and omega-3s[30].

Remember, individual needs may vary, and it’s crucial to work with a healthcare professional to tailor nutritional approaches to your specific situation. An anti-inflammatory, nutrient-dense diet can be a powerful tool in supporting recovery from neurological Lyme disease when combined with appropriate medical treatment.

Infrared Sauna Therapy

Read More

^{[1] https://www.neurologyadvisor.com/features/lyme-neuroborreliosis-expert-key-insights-diagnosis-treatment-paul-auwaerter-md/
[2] https://www.amazon.com/Top-Lyme-Disease-Treatments-Conventional/dp/0976379716
[3] https://www.theatlantic.com/magazine/archive/2019/09/life-with-lyme/594736/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174852/
[5] https://www.today.com/health/disease/mom-shares-neurologic-lyme-symptoms-rcna150245
[6] https://www.youtube.com/watch?v=HUtnvzqunkw
[7] https://www.lymediseaseaction.org.uk/about-lyme/neurology-psychiatry/
[8] https://www.mayoclinic.org/diseases-conditions/lyme-disease/diagnosis-treatment/drc-20374655
[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146759/
[10] https://www.lymediseaseaction.org.uk/about-lyme/neurology-psychiatry/
[11] https://www.columbia-lyme.org/diagnosis
[12] https://www.medicalnewstoday.com/articles/neurologic-lyme-disease
[13] https://www.hopkinslyme.org/lyme-disease/diagnosis-of-lyme-disease/
[14] https://www.neurologyadvisor.com/features/lyme-neuroborreliosis-expert-key-insights-diagnosis-treatment-paul-auwaerter-md/
[15] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174852/
[16] https://www.neurologyadvisor.com/features/what-its-like-to-live-with-neurologic-lyme-disease-a-patient-perspective/
[17] https://drtoddmaderis.com/methylene-blue-for-lyme-disease-and-bartonella
[18] https://rhealthc.com/lyme-disease/methylene-blue-in-the-treatment-of-chronic-lyme-disease/
[19] https://sanctuaryfunctionalmedicine.com/topics/lyme-and-chronic-infections/methylene-blue-for-tick-borne-infections/
[20] https://tccompound.com/animal-medications/methylene-blue-capsules-lyme-bartonella/
[21] https://www.lymedisease.org/methylene-blue-lyme-disease/
[22] https://www.youtube.com/watch?v=Cq4-iT0SjNE
[23] https://www.compoundingcenter.com/blog/methylene-blue-lyme-disease
[24] https://projectlyme.org/methylene-blue/
[25] https://www.youtube.com/watch?v=Cq4-iT0SjNE
[26] https://www.testing.com/tests/g6pd/
[27] https://medlineplus.gov/lab-tests/g6pd-test/
[28] https://stramcenter.com/blog/blog-detail/optimal-nutrition-crucial-to-lyme-regimen/
[29] https://www.globallymealliance.org/blog/how-to-optimize-your-lyme-disease-recovery-with-nutrition-1
[30] https://www.lymedisease.org/how-good-nutrition-can-help-you-recover-from-lyme-disease/
[31] https://www.todaysdietitian.com/newarchives/0221p38.shtml
[32] https://igenex.com/tick-talk/lyme-disease-diet/
[33] https://www.medicalnewstoday.com/articles/lyme-disease-diet
[34] https://kresserinstitute.com/help-clients-recover-from-lyme-disease-with-diet-and-nutrition/
[35] https://www.peakhealthinstitute.com/the-best-diet-for-lyme-disease/}