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One thought on “RFK Jr.’s Blue Elixir: Methylene Blue, Its Benefits and Risks”
FYI: Low-dose oral methylene blue is primarily used as an aid to improve detection and staging in colorectal cancer (CRC), rather than as a direct treatment or preventive agent. Studies show that methylene blue injection or staining techniques significantly increase lymph node harvest during surgical specimen evaluation, which improves staging accuracy and may be associated with better long-term survival, especially in early-stage CRC. However, methylene blue itself does not directly kill cancer cells like chemotherapy. Its anticancer potential is being explored mainly in photodynamic therapy (PDT), where methylene blue acts as a photosensitizer activated by light to produce reactive oxygen species that can reduce tumor size. While promising, this approach is still under research and not yet standard for treatment or prevention. There is currently no strong evidence that oral methylene blue prevents colorectal cancer. Thus, methylene blue’s role in CRC is mainly as a diagnostic and adjunctive tool rather than a standalone treatment or preventive measure.
FYI: Low-dose oral methylene blue is primarily used as an aid to improve detection and staging in colorectal cancer (CRC), rather than as a direct treatment or preventive agent. Studies show that methylene blue injection or staining techniques significantly increase lymph node harvest during surgical specimen evaluation, which improves staging accuracy and may be associated with better long-term survival, especially in early-stage CRC. However, methylene blue itself does not directly kill cancer cells like chemotherapy. Its anticancer potential is being explored mainly in photodynamic therapy (PDT), where methylene blue acts as a photosensitizer activated by light to produce reactive oxygen species that can reduce tumor size. While promising, this approach is still under research and not yet standard for treatment or prevention. There is currently no strong evidence that oral methylene blue prevents colorectal cancer. Thus, methylene blue’s role in CRC is mainly as a diagnostic and adjunctive tool rather than a standalone treatment or preventive measure.
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC11169040/
[2] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1264961/full
[3] https://www.sciencedirect.com/science/article/pii/S0960740424000148?dgcid=rss_sd_all
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC10568458/
[5] https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610742/full
[6] https://www.drugs.com/medical-answers/methylene-blue-kill-cancer-cells-3580047/
[7] https://www.macsenlab.com/blog/methylene-blue-for-cancer-therapy/
[8] https://journals.lww.com/ijpm/fulltext/2016/59040/impact_of_methylene_blue_staining_in_the_retrieval.13.aspx