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New related: Fat cells actively store energy in lipid droplets and release it when needed via the enzyme hormone-sensitive lipase (HSL), which is activated by hormones like adrenaline. Surprisingly, loss of HSL causes lipodystrophy—reduced fat mass—because HSL also functions inside adipocyte nuclei to regulate gene programs that maintain healthy fat tissue; disruption of this nuclear role helps explain why HSL deficiency leads to fat loss rather than obesity. This dual role of HSL links dysfunction in both obesity and lipodystrophy to impaired adipocyte function and points to new targets for understanding and treating metabolic disease.
Focus on sustained calorie deficit through a mix of reduced calorie intake and regular exercise (strength training plus aerobic activity) to shrink fat stores while supporting metabolic health—consult a doctor before major changes.
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New related: Fat cells actively store energy in lipid droplets and release it when needed via the enzyme hormone-sensitive lipase (HSL), which is activated by hormones like adrenaline. Surprisingly, loss of HSL causes lipodystrophy—reduced fat mass—because HSL also functions inside adipocyte nuclei to regulate gene programs that maintain healthy fat tissue; disruption of this nuclear role helps explain why HSL deficiency leads to fat loss rather than obesity. This dual role of HSL links dysfunction in both obesity and lipodystrophy to impaired adipocyte function and points to new targets for understanding and treating metabolic disease.
Focus on sustained calorie deficit through a mix of reduced calorie intake and regular exercise (strength training plus aerobic activity) to shrink fat stores while supporting metabolic health—consult a doctor before major changes.